Researchers at ETH Zurich have developed a cell culture test to detect substances that are directly or indirectly harmful to embryos. Based on an existing test used for developing new drugs and chemicals, the augmented version is designed to help reduce the number of animal experiments.
In the animal kingdom, it’s the ladies who get to pick their partners. So if males want to mate, they have to woo females and outshine their rivals. UZH biologist Stefan Lüpold examines what gives male animals the edge when it comes to sexual selection.
Increased stress, lack of exercise and frequent snacking: The effects of the pandemic are visible on our waistlines. For endocrinologist Philipp Gerber, the weight gain is not just a short-term side effect, but is storing up problems for the future and needs to be taken seriously.
Today, molecular genetic methods can be used to breed sustainable crops - such as multinutrient rice. Researchers are calling for the risk of new plant varieties to be assessed not on the basis of the breeding method, but on the basis of their characteristics.
Researchers at ETH Zurich and the University of Basel have developed a vaccine that protects animals from Salmonella. These bacteria often escape the effects of vaccination by genetically modifying their protective coat. The researchers have succeeded in manipulating this process to lure the bacteria into an evolutionary trap.
Researchers from ETH Zurich and University of Zurich have developed a new microscopy technique that lights up the brain with high resolution imagery. This allows neuroscientists to study brain functions and ailments more closely and non-invasively.
Researchers from ETH Zurich and the University of Zurich deciphered the cellular mechanisms through which tendons can adapt to mechanical stresses. People who carry a certain variant of a gene that is key to this mechanism show improved jumping performance.
The world’s largest terrestrial conservation area is located in southern Africa and covers 520,000 square kilometers spanning five countries. A study from the University of Zurich now shows that the endangered African wild dog mostly remains within the boundaries of the Kavango-Zambezi Transfrontier Conservation Area (KAZA) when dispersing, thus highlighting the relevance of such a large-scale conservation initiative for maintaining key wildlife corridors of threatened species.
SARS-CoV-2 is critically dependent on a special mechanism for the production of its proteins. A collaborative team led by a research group at ETH Zurich obtained molecular insights into this process and demonstrated that it can be inhibited by chemical compounds, thereby significantly reducing viral replication in infected cells.
ETH Fellow Serina Robinson is devoted to microorganisms. She is particularly interested in the enzymes they use to produce and break down chemical substances. The young scientist is also especially fascinated by as yet uncultivated microbes.
Is Marian Neidert taking a saw to the branch he’s sitting on? As a neurosurgeon, he operates on brain tumors; as a researcher he’s trying to teach the immune system to fight them itself. But it might be some time before immunotherapies make surgery superfluous
Biologist Marcel van der Heijden aims to increase agricultural yields – not just with artificial fertilizers, pesticides, and GM technology, but also fungi and other microorganisms. He's not afraid to resort to less conventional research methods, either.
Bacteria can survive antibiotic treatment even without antibiotic resistance by slowing down their metabolism and going into a type of deep sleep. A research team reveals the changes bacteria undergo to reach this "persister" state. Annelies Zinkernagel, an infectiologist at UZH, is main author of the publication in the scientific journal PNAS.
ETH researchers have found a gene mutation that causes the sperm of boars to immobilize. Their discovery will help pig breeders to exclude animals with this genetic defect from breeding in future.
Most of the time, our brain receives different input from each of our ears, but we nevertheless perceive speech as unified sounds. This process takes place through synchronization of the areas of the brain involved with the help of gamma waves, neurolinguists at the University of Zurich have now discovered. Their findings may lead to new treatment approaches for tinnitus.
We often hear that Swiss consumers want their agriculture to be free from genetic engineering. But consumer acceptance of genetically modified crops is likely to be higher than the media leads us to believe, Angela Bearth says.
Human communication is much more complex than all other forms of animal communication. And yet, monkeys and meerkats are also able to use language. Research into animal languages can help us understand how human language evolved.
Artificial intelligence can help predict the three-dimensional structure of proteins. Beat Christen describes how such algorithms should soon help to develop tailored artificial proteins.
Adenoviruses have a linchpin protein that stabilizes their DNA until it reaches the infected cell’s nucleus. The protein then detaches from the viral genome, and the virus uncoats. Only then are the genes released into the nucleus, which is necessary for the production of new viruses. This process, discovered by researchers at the University of Zurich, is a key for effective functioning of various Covid-19 vaccines.
ETH pharmaceutical sciences graduate Nicole Stoffel has shown that iron deficiency reduces vaccine efficacy. Her research is now helping to improve the health of children in developing countries – yet becoming a researcher was not originally part of her plans.
ETH researchers Michele Gregorini and Philippe Bechtold have developed a PCR testing device that can easily be used outside the lab – and that takes less than 30 minutes to deliver results. Now the two young entrepreneurs are focusing their efforts on getting the device approved for medical use.
Resistance to antibiotics is increasing and can be found all over – in humans, animals, plants and the environment. To stop the spread of antibiotic resistance, we need to understand how it is transmitted and how we can prevent this from happening.
Chronic stress can decrease the quality of our lives, and have long-term negative effects on our health that may be irreversible. The new «Hochschulmedizin Zürich (HMZ)» flagship project STRESS aims to explore the causes of stress and highlight possible treatments.
Bacteria that are resistant to antibiotics and pathogens that spread from animals to humans are posing major problems for medicine. To combat them, researchers from various fields need to work hand in hand. This approach has become known as One Health.