The Achilles heel of the Coronavirus

The RNA (yellow) of the SARS-​CoV-2 virus forms a pseudoknot structure (multicolored, bottom right) which leads to a shift in the reading frame of the ribosome (brown). In this way, the viral RNA controls the production levels of the viral proteins. (Graphic: Said Sannuga, / ETH Zurich, The Ban Lab)

SARS-​CoV-2 is critically dependent on a special mechanism for the production of its proteins. A collaborative team led by a research group at ETH Zurich obtained molecular insights into this process and demonstrated that it can be inhibited by chemical compounds, thereby significantly reducing viral replication in infected cells.

Youtube Video (Video: Said Sannuga, / ETH Zurich, The Ban Lab)

ETH News

Silvie Cuperus