Refining Breast Cancer Classification by Multiplexed Imaging

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35 protein biomarkers create an unprecedented view of a tumor’s cellular landscape and the surrounding tissue. (Image: Bernd Bodenmiller / UZH)

An imaging approach developed at UZH enables the study of breast cancer tissue in greater detail. It uses 35 biomarkers to identify the different cell types in breast tumors and its surrounding area compared to the current standard of testing single markers. This increases the precision of tumor analysis and classification - and improves personalized diagnostics for breast cancer patients.

Breast cancer progression can vary significantly between patients. Even within the same tumor, different areas may be composed of different types of cells and characterized by different tumor structures. This heterogeneity makes it challenging to ascertain the severity of a tumor and assess its molecular subtype, thereby affecting the precision of diagnosis and the choice of the most effective treatment approach. More detailed characterization of a breast cancer tissue could help improve a treatment’s chances of success and may decrease the risk of relapse.

Press release UZH

Silvie Cuperus

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